Berberine in fish nutrition: Impact on hepatoenteric health, antioxidative and immune status

Berberine, an isoquinoline alkaloid found in some traditional medicinal plants, such as Berberis vulgaris and Coptis Chinensis , has been considered effective drug treating obesity, hypertension, type-2 diabetes, hyperlipidemia, gout humans animals. It currently certain applications fish nutrition health, mainly because it strong biological pharmacological properties, antioxidative, anti-inflammation, antidiarrheal, analgesic, antimicrobial, anticancer, hepatoprotective, lipid- glucose-lowering properties. Recent studies revealed that berberine supplementation different diets could alleviate liver pathological changes, intestinal histological microbiota alterations caused by high lipid carbohydrate diets, well improve growth performance, antioxidative immune status, stress resistance ability of fish. However, the beneficial effects vary with species, basal diet, feeding modes, level, etc. This review highlights bioavailability toxicity berberine, its mechanisms glucose metabolism, antioxidation, protection other findings on supplementing diet. Moreover, this provides future perspectives application health.